User:Vitaly Balan

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CURRICULUM VITAE of VITALY BALAN


EDUCATION 1999 – 2004 Ph.D. in Molecular Biology & Biochemistry University of Ben-Gurion, Israel (Advisors: Prof. Ze’ev Barak and Prof. David Chipman) 1995 – 1998 M.Sc. in Molecular Biology & Biochemistry University of Ben-Gurion, Israel (Advisors: Prof. Ze’ev Barak and Prof. David Chipman) 1988 – 1993 B.Sc. in Biology & Chemistry Tiraspol State University, Moldova POSITIONS AND EMPLOYMENT 2011-present Assistant Professor, Department of Oncology, Wayne State University, Karmanos Cancer Institute, Detroit, MI USA

2006-2011 Research Associate, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, MI USA (supervisor Dr. Avraham Raz)

2004-2006 Postdoctoral Research Fellow, Karmanos Cancer Institute, Department of Pathology, Wayne State University, Detroit, MI USA (supervisor Dr. Guri Tzivion) 2003-2004 Postdoctoral Research Fellow, CVRI, Texas A&M University, Temple, TX (supervisor Dr. Guri Tzivion) 1998-2003 Research Graduate/Assistant Teacher, Department of Life Sciences, University of Ben-Gurion, Israel. 1996-1998 Research Assistant/Assistant Teacher, Department of Life Sciences, University of Ben-Gurion, Israel.



PUBLICATIONS

Dobson, M., Ramakrishnan, G., Ma, S., Kaplun, L., Balan, V., Fridman, R., Tzivion, G. Bimodal Regulation of FoxO3 by AKT and 14-3-3. Biochimica et Biophysica Acta Mol Cell Research, 2011 Aug; 1813 (8): p. 1453-64

Wang, Y., Nangia-Makker, P, Balan, V., Hogan, V., Raz, A. Calpain activation through galectin-3 inhibition sensitizes prostate cancer cells to cisplatin treatment. Cell Death & Disease, 2010 Nov; vol. 1 (11) pp. e101, doi: 10.1038/cddis.2010.79

Balan, V1., Nangia-Makker, P., Jung, Y.S., Wang, Y., and Raz, A. Galectin-3: A novel substrate for c-Abl kinase. Biochimica et Biophysica Acta Mol Cell Research, 2010 June; 1803 (10): p. 1198-205. 1 Corresponding author

Balan, V., Nangia-Makker, P., Raz, A. Galectins as biomarkers. Cancers 2010 Apr; 2 (2): p. 592-610

Nangia-Makker, P., Wang, Y., Raz, T., Tait, L., Balan, V., Hogan, V., Raz, A. Cleavage of galectin-3 by matrix metalloproteases induces angiogenesis in breast cancer. Int J Cancer, 2010 Dec; 1; 127 (11): p. 2530-41 Featured paper

Wang, Y., Nangia-Makker, P., Tait, L., Balan, V., Hogan, V., Pienta, KJ., Raz, A. Regulation of prostate cancer progression by galectin-3. Am J Pathol 2009 Apr; 174 (4): (1515-1523)

Balan, V., Nangia-Makker, P., Schwartz, A. G., Jung, Y. S., Tait, L., Hogan, V., Raz, T., Wang, Y., Yang, Z. Q., Wu, G. S., Guo, Y., Li, H., Abrams, J., Couch, F. J., Lingle, W. L., Lloyd, R. V., Ethier, S. P., Tainsky, M. A., and Raz, A. Racial disparity in breast cancer and functional germ line mutation in galectin-3 (rs4644): a pilot study, Cancer Res 2008 Dec; (68): p. 10045-10050 Featured paper

Balan, V., Miller, GS., Kaplun, L., Balan, K., Chong, ZZ., Li, F., Kaplun, A., VanBerkum, MF., Arking, R., Freeman, DC., Maiese, K., and Tzivion, G. Lifespan extension and neuronal cell protection by Drosophila nicotinamidase. JBC 2008 Oct; 238 (41): p. 27810-27819

Nangia-Makker, P., Balan, V., Raz, A. Regulation of Tumor Progression by Extracellular Galectin-3. Cancer Microenvironment 2008 Feb; 20 (1875-2284)

Leicht, D. T., Balan, V., Kaplun, A., Singh-Gupta, V., Kaplun, L., Dobson, M., and Tzivion, G. Raf kinases: Function, regulation and role in human cancer, Biochim Biophys Acta 2007 May; 1773 (8): p. 1196-1212

Balan, V., Leicht, D., Zhu, J., Balan, K., Singh, V., Qin, J., and Tzivion, G. Identification of novel in vivo Raf phosphorylation sites mediating positive feedback Raf regulation by ERK-1. Mol Biol Cell 2006 Mar; 17 (3): p. 1141-53

Tzivion, G., Singh, V., Kaplun L., Balan, V. 14-3-3 proteins as potential oncogenes. Semin Cancer Biol. 2006 Jun; 16 (3): p. 203-213

  • Zhu, J., *Balan, V., Bronisz, A., Balan, K., Sun, H., Leicht, D., Luo, Z., Qin, J., Avruch, J., Tzivion, G. Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell 2005 Oct; (16): p. 4733–4744
  • These authors contributed equally to this work.

Bar-Ilan, A., Balan, V., Titmann, K., Vyazmensky, M., Hubher, G., Barak, Z., Chipman, D. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase. Biochemistry 2001 Oct 2; 40 (39): p. 11946-54

Book Chapters:

Nangia-Makker, P., Balan, V., Raz, A. Galectin-3 Binding and Metastasis. In: Methods in Molecular Medicine: Metastasis Research Protocols. Dr Brooks S. and Schumacher U. (Ed.), Humana Press, in press

Wang, Y., Balan, V., Raz, A. Galectin-3 and cancer. In: Animal Lectins: A Functional View. Vasta GR. and Ahmed H. (Ed.), CRC Press (Taylor and Francis group), p. 195-206, 2009

Presentations: • Balan V, Nangia-Makker P, Raz A. The interplay between prostate specific antigen and galectin-3 during prostate cancer progression. Abstract at the Gordon Research Conference on Matrix Metalloproteinases (2011) Smithfield, RI • Balan V, Nangia-Makker P, Raz A. Tyrosine Phosphorylation of Galectin-3 Regulates its Cleavage by PSA [abstract]. In: Proceedings of the 102th Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; 2011. Abstract nr 1495 • Balan V, Nangia-Makker P, Raz A. The role of tyrosine phosphorylation in galectin-3 regulated cell motility [abstract]. In: Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 2166 • Balan, V., Nangia-Makker, P., Raz, A., (2008) Galectin-3 nsSNP rs4644 Foretells Human Breast Cancer Risk Associated With Racial Disparity [abstract]. In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research, San Diego, CA, USA • Balan, V., Kaplun, A., Tzivion, G., (2007) Alanine mutation scanning of Raf-1 reveals novel residues important for its activation. Abstract at the FASEB Summer Research Conference "Protein Kinases & Protein Phosphorylation", Indian Wells, CA, USA. • Balan, V., Leicht, D., Tzivion, G., (2006) Raf-1 Regulation by Novel Phosphorylations. Abstract at the Gordon Research Conference, New London, CT, USA • Balan, V., Balan, K., Leicht, D., Tzivion, G., (2005) Identification of Novel In Vivo Raf-1 Phosphorylation Sites Mediating Positive Feedback Raf-1 Regulation Targeted By ERK. Abstract at the FASEB Research Conference, Snowmass, CO, USA • Balan, V., Leicht, D., Balan, K., Singh-Gupta, V., Tzivion, G. (2005) Regulation of Raf-1 By Phosphorylation and Protein Interactions. Abstract at the FASEB Research Conference, Snowmass, CO, USA • Balan, V., Bronisz, A., Sun, H., Godlewski, J., Shen, YH., Zhu, J., Tzivion, G., (2004) 14-3-3 Regulation, An Interplay Of Phosphorylation, Dimerization And Sequestration. Abstract at the Gordon Research Conference, Ventura, CA, USA • Tzivion, G., Shen, YH., Godlewski, J., Balan, V., Sun, H., Zhu, J. and Bronisz, M. (2004) Role of 14-3-3 Proteins in Tumorigenesis; Use of a Transgenic 14-3-3 Mouse Line as a Model. Presentation at the Gordon Research Conference on "Biology of 14-3-3 Proteins", Ventura, CA, USA. • Tzivion, G., Zhu, J., Bronisz, A., Balan, V., Cain, J., Godlewski, J., (2003) Identification of Raf phosphorylation site(s) critical for Raf kinase activity and MEK binding provides a new approach for the development of Raf/MEK inhibitors. Abstract at the SALK/EMBL meeting on Oncogenes and Growth Control, La Jolla, CA, USA • Balan, V., Kaplun, A., Barak, Z., Chipman, D. (2001) Thiamin diphosphate binding and the assembly of acetohydroxyacid synthase. Abstract at the International Conference on Thiamin, its Biochemistry, and Structural Biology, Newark, NJ, USA • Balan, V., Barak, Z., Chipman, D. (1998) Amino Acids Responsible for Mg2+ Binding in Acetohydroxy Acid Synthase. Abstract at the 25th Silver Jubilee FEBS Meeting, Copenhagen, Denmark • Balan, V., Bar-Ilan, A., Barak, Z., Chipman, D., Mendel S., and Vyazmensky, M. (1998) Study of the Catalytic site of Acetohydroxy Acid Synthase II by Directed Mutagenesis. Abstract at the 2nd Conferences of Federation of the Israeli Society of Experemental Biology, Eilat, Israel

Invited Seminars: 1. Wayne State University, Karmanos Cancer Institute, August 15, 2006

2. Wayne State University, Department of Pathology, September 15, 2010

3. Wayne State University, Department of Oncology, January 21, 2011

4. Wayne State University, Karmanos Cancer Institute, Molecular Biology&Genetics Program Meeting, March 8, 2011


MEMBERSHIPS American Association for Cancer Research


RESEARCH PROJECTS ONGOING, PENDING OR COMPLETED

Ongoing Research Support:

IRG #11-053-01-IRG Title of project: The interplay between prostate specific antigen and galectin-3 during prostate cancer progression. Funding Source: American Cancer Society Role: Principal Investigator Performance Period: 9-01-2011 to 8-31-2012

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