Welcome to the CFG Paradigm Pages

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Consult the [http://meta.wikimedia.org/wiki/Help:Contents User's Guide] for information on using the wiki software.
Consult the [http://meta.wikimedia.org/wiki/Help:Contents User's Guide] for information on using the wiki software.
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== Main Page ==
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'''The CFG Paradigms'''
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The [[Consortium for Functional Glycomics (CFG)]] is a large research initiative, funded by NIGMS, and formed to define the paradigms by which protein-carbohydrate interactions mediate cell communication. The strategy to achieve this goal is to work with the scientific community to create unique resources and services that Participating Investigators can utilize in their own research. Data produced by the Scientific Cores, much of which is generated using samples provided by investigators, are uploaded into the CFG relational database, the primary vehicle for integrating data across platforms and for dissemination of data to investigators and to the scientific community. Specialty databases for glycan-binding proteins, glycan structures, and glycosyltransferases are available. Participating Investigators who use CFG resources in their own research programs are publishing their findings in scientific articles and reviews; the rate of new publications involving CFG resources is more than doubling each year. The vision to harness the cumulative research of Participating Investigators and data produced by the CFG Scientific Cores will be a major force in achieving the CFG's goals.
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The purpose of this section of the CFG database is to document the success of the CFG in achieving its overall goal to 'define paradigms by which protein-carbohydrate interactions mediate cell communication.' Below are the paradigms chosen by the CFG steering committee, subgroup leaders, and other participating investigators to represent each of the major classes of glycan-binding proteins (GBP). Follow the links to each paradigm for more information and to contribute to a Wiki page describing how the CFG and its PIs have contributed to the understanding of that GBP.
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==
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C-type lectins ==
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The C-type lectin family consists of proteins with diverse overall organization that contain structurally related carbohydrate-recognition domains. Although they generally share a common mechanism for interacting with sugars through a bound calcium ion, the spectrum of ligands bound by different members of the family is diverse and can include both endogenous mammalian oligosaccharides as well a sugar-containing structures on pathogenic micro-organisms. The biological functions of the C-type lectins are correspondingly diverse, but many of the best understood examples are membrane receptors found on the surface of cells of the immune system, which mediate interactions of these cells with each other and with viruses, bacteria, fungi and parasites, while other members of the family are soluble mediators of innate immunity. Outside the immune system, members of this group participate in clearance of circulating glycoproteins
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Paradigm 1: DC-Sign
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Paradigm 2: Macrophage galactose lectin (MGL)
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Paradigm 3: LSECtin
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Paradigm 4: P-Selectin
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Paradigm 5: Mannose receptor
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Paradigm 6: Ficolins or Mannose-binding protein

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The CFG Paradigms


The purpose of this section of the CFG database is to document the success of the CFG in achieving its overall goal to 'define paradigms by which protein-carbohydrate interactions mediate cell communication.' Below are the paradigms chosen by the CFG steering committee, subgroup leaders, and other participating investigators to represent each of the major classes of glycan-binding proteins (GBP). Follow the links to each paradigm for more information and to contribute to a Wiki page describing how the CFG and its PIs have contributed to the understanding of that GBP.


== C-type lectins ==

The C-type lectin family consists of proteins with diverse overall organization that contain structurally related carbohydrate-recognition domains. Although they generally share a common mechanism for interacting with sugars through a bound calcium ion, the spectrum of ligands bound by different members of the family is diverse and can include both endogenous mammalian oligosaccharides as well a sugar-containing structures on pathogenic micro-organisms. The biological functions of the C-type lectins are correspondingly diverse, but many of the best understood examples are membrane receptors found on the surface of cells of the immune system, which mediate interactions of these cells with each other and with viruses, bacteria, fungi and parasites, while other members of the family are soluble mediators of innate immunity. Outside the immune system, members of this group participate in clearance of circulating glycoproteins

Paradigm 1: DC-Sign Paradigm 2: Macrophage galactose lectin (MGL) Paradigm 3: LSECtin Paradigm 4: P-Selectin Paradigm 5: Mannose receptor Paradigm 6: Ficolins or Mannose-binding protein

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