MAG
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== Acknowledgements == | == Acknowledgements == | ||
| - | The CFG is grateful to the following PIs for their contributions to this wiki page: Paul Crocker, James Paulson | + | The CFG is grateful to the following PIs for their contributions to this wiki page: Paul Crocker, Sorge Kelm, James Paulson, Ron Schnaar |
Revision as of 17:54, 13 May 2010
Myelin-associated glycoprotein (MAG, Siglec-4) is unique among the siglecs in that it is expressed exclusively on neuronal glial cells[1][2]. It is the most highly conserved among the siglecs in mammalian species. This siglec paradigm is unique in its activity for stabilizing axon-myelin interactions. MAG has a cytoplasmic domain that is devoid of ITIMs, but contains a tyrosine-based motif associated with binding the FYN tyrosine kinase, believed to play a role in its activity in myelin-axon interactions. MAG recognizes as ligands sialoside sequences found on gangliosides that are abundant in axonal membranes[2]. It is one of several proteins in myelin that negatively regulate axon outgrowth following tissue injury, an activity that involves MAG ligand interactions. Evidence suggests that inhibition of MAG ligand interactions may enhance neurite outgrowth and repair of injured neurons[3][4].
Contents |
CFG Participating Investigators contributing to the understanding of this paradigm
Several CFG Participating Investigators (PIs) have contributed to identification of MAG as a siglec and to understanding the functions of MAG, including: Paul Crocker, Sørge Kelm, James Paulson, Ronald Schnaar
Progress toward understanding this GBP paradigm
Carbohydrate ligands
Cellular expression
Myelinating cells like oligodendrocytes or Schwann cells
Structure
Biological roles of GBP-ligand interaction
CFG resources used in investigations
The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for Siglec-4.
Glycan profiling
Glycogene microarray
Knockout mouse lines
The CFG has phenotyped the MAG-deficient mouse.
Glycan array
Investigators have used CFG carbohydrate compounds to study MAG ligand specificity.
Related GBPs
None.
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References
- ↑ Crocker, P. R., Paulson, J. C. & Varki, A. Siglecs and their roles in the immune system. Nat Rev Immunol 7, 255-266 (2007).
- ↑ 2.0 2.1 Schnaar, R. L. Brain gangliosides in axon-myelin stability and axon regeneration. FEBS Lett (2009).
- ↑ Yang, L. J. et al. Sialidase enhances spinal axon outgrowth in vivo. Proc Natl Acad Sci U S A 103, 11057-11062 (2006).
- ↑ Vyas, A. A., Blixt, O., Paulson, J. C. & Schnaar, R. L. Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro. J Biol Chem 280, 16305-16310 (2005).
Acknowledgements
The CFG is grateful to the following PIs for their contributions to this wiki page: Paul Crocker, Sorge Kelm, James Paulson, Ron Schnaar
