LSECtin

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=== Knockout mouse lines ===
=== Knockout mouse lines ===
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LSECtin knockout mice were created by the CFG and are in the queue for [https://www.functionalglycomics.org/glycomics/publicdata/phenotyping.jsp phenotype] analysis in 2010/11.
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LSECtin knockout mice were created by the CFG ([https://www.functionalglycomics.org/static/consortium/resources/DataCoreFCG.shtml LSECtin-total knockout] and [https://www.functionalglycomics.org/static/consortium/resources/DataCoreFCG.shtml LSECtin-conditional knockout])  and are in the queue for [https://www.functionalglycomics.org/glycomics/publicdata/phenotyping.jsp phenotype] analysis in 2010/11.
=== Glycan array ===
=== Glycan array ===
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== References ==
== References ==
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Powlesland AS, Fisch T, Taylor ME, Smith DF, Tissot B, Dell A, Phölmann S, Drickamer K (2008) A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans. J Biol Chem 283, 593-602.
== Acknowledgements ==
== Acknowledgements ==
The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk
The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk

Revision as of 23:53, 5 April 2010

LSECtin serves a model for other members of the C-type lectin family that are expressed on sinusoidal endothelial cells and facilitate viral infection, but lack endocytic function.

Contents

CFG Participating Investigators contributing to the understanding of this paradigm

Several PIs are working on ligand-binding specificity of LSECtin and interaction of this C-type lectin with viral pathogens.

  • PIs working on LSECtin include: Angel Corbi, Kurt Drickamer, Maureen Taylor
  • PIs working on L-SIGN/DC-SIGNR include: Ben Appelmelk, Angel Corbi, Kurt Drickamer, Benhur Lee, Maureen Taylor, Yvette van Kooyk, Bill Weis

Progress toward understanding this GBP paradigm

Carbohydrate ligands


Cellular expression


Structure


Biological roles of GBP-ligand interaction


CFG resources used in investigations

The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for LSECtin.

Glycan profiling


Glycogene microarray


Knockout mouse lines

LSECtin knockout mice were created by the CFG (LSECtin-total knockout and LSECtin-conditional knockout) and are in the queue for phenotype analysis in 2010/11.

Glycan array

Glycan array analysis of LSECtin has revealed unusually high selectivity for specific ligands.

Related GBPs

L-SIGN / DC-SIGNR

References

Powlesland AS, Fisch T, Taylor ME, Smith DF, Tissot B, Dell A, Phölmann S, Drickamer K (2008) A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans. J Biol Chem 283, 593-602.

Acknowledgements

The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk

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