Galectin-3

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== Acknowledgements ==
== Acknowledgements ==
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The CFG is grateful to the following PIs for their contributions to this wiki page: Linda Baum, Richard Cummings
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The CFG is grateful to the following PIs for their contributions to this wiki page: Linda Baum, Richard Cummings, Fu-Tong Liu

Revision as of 17:51, 13 May 2010

Galectin-3...

  • is the only member of chimeric subfamily in mammals
  • is a very well-studied glycan-binding protein (GBP)
  • crystal structure is known
  • has unique functions intra- and extra-cellularly, due to unusual N-terminal domain that can participate in protein-protein interactions
  • has a unique mode of multimerization
  • is the only known anti-apoptotic galectin
  • null mice have distinct phenotypes, including alterations in inflammatory and wound-healing responses, and cyst formation in disease[1]
  • has unique functions in innate immune response to microbial pathogens
  • has been administered in animal models of disease to assess therapeutic potential
  • binds distinct cell surface glycoprotein ligands in lymphocytes compared to Galectin-16
  • expression is involved in growth modulation[2]
  • has anti-apoptotic activity in its intracellular expression[3]

Contents

CFG Participating Investigators contributing to the understanding of this paradigm

CFG Participating Investigators (PIs) contributing to the understanding of Galectin-3 include: Linda Baum, Susan Bellis, Roger Chammas, Richard Cummings, James Dennis, Margaret, Huflejt, Fu-Tong Liu, Joshiah Ochieng, Noorjahan Panjawani, Mauro Perretti, Avram Raz, James Rini, Maria Roque-Barreira, Sachiko Sato, Tariq Sethi, Irma van Die, Gerardo Vasta, John Wang, Paul Winyard

Progress toward understanding this GBP paradigm

Carbohydrate ligands


Cellular expression


Structure


Biological roles of GBP-ligand interaction


CFG resources used in investigations

The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for Galectin-3.

Glycan profiling


Glycogene microarray


Knockout mouse lines

Galectin-3 knockout mice were phenotyped by the CFG and continue to be used by investigators to study the biological functions of Galectin-3.

Glycan array

Investigators have used CFG carbohydrate compounds and glycan array to study ligand binding specificity of Galectin-3.

Related GBPs

None in mammals, homologues in invertebrates.

References

  1. Chiu, M.G. et al. Galectin-3 associates with the primary cilium and modulates cyst growth in congenital polycystic kidney disease. Am J Pathol 169, 1925-1938 (2006).
  2. Baptiste, T.A., James, A., Saria, M. & Ochieng, J. Mechano-transduction mediated secretion and uptake of Galectin-3 in breast carcinoma cells: implications in the extracellular functions of the lectin. Exp Cell Res 313, 652-664 (2007).
  3. Saegusa, J. et al. Galectin-3 protects keratinocytes from UVB-induced apoptosis by enhancing AKT activation and suppressing ERK activation. J Invest Dermatol 128, 2403-2411 (2008).

Acknowledgements

The CFG is grateful to the following PIs for their contributions to this wiki page: Linda Baum, Richard Cummings, Fu-Tong Liu

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