DC-SIGN

From CFGparadigms

Revision as of 23:31, 1 April 2010 by Heather Buschman (Talk | contribs)
Jump to: navigation, search

DC-SIGN is a C-type lectin that plays roles in both cell-cell and host-pathogen interactions, and thus serves as a model for both processes. This glycan-binding protein (GBP) paradigm also serves as a model for other members of the C-type lectin family expressed on dendritic cells.


Contents

CFG Participating Investigators contributing to the understanding of this paradigm

Many investigators, both CFG Participating Investigators (PIs) and non-PIs using CFG resources, have led extensive studies on DC-SIGN, particularly regarding structure-function relationships, interactions with pathogens, and signaling functions in dendritic cells.

PIs:

  • Pedro Bonay
  • Angel Corbi
  • Kurt Drickamer
  • Juan Garcia-Vallejo
  • Donald Harn
  • Kayo Inaba
  • Benhur Lee
  • Olivier Neyrolles
  • Irma van Die
  • Yvette van Kooyk
  • William Weis
  • Martin Wild

Non-PIs with who have used CFG resources:

  • Brigitte Gicquel
  • Arne Skerra
  • Ralph Steinman

Progress toward understanding this GBP paradigm

Carbohydrate ligands


Cellular expression


Structure


Biological roles of GBP-ligand interaction


CFG resources used in investigations

The best examples of CFG contributions to this paradigm are described below, with links to specific data sets. For a complete list of CFG data and resources relating to this paradigm, see the CFG database search results for DC-SIGN.

Glycan profiling


Glycogene microarray


Knockout mouse lines

Knockout mice for three potential DC-SIGN orthologues (DC-SIGN, LSECtin-total knockout, and LSECtin-conditional knockout) were created by the CFG and distributed to PIs, and their phenotypes were analyzed.

Glycan array

Glycan array analysis and synthetic oligosaccharides were used to elucidate DC-SIGN glycan-binding specificity and analyze the mechanism of specific glycan binding.


Related GBPs

Other dendritic cell lectins include langerin, DCIR, and DCAR. Paralogs on other cells include DC-SIGNR.

References


Acknowledgements

The CFG is grateful to the following PIs for their contributions to this wiki page: Kurt Drickamer, Yvette van Kooyk

Personal tools